General description
A potent, cell-permeable and irreversible inhibitor of caspase-5 (ICErel-III, TY), as well as caspase-1 and caspase-4.
A potent, cell-permeable, and irreversible inhibitor of caspase-5. Strongly inhibits caspase-1. Also inhibits caspase-4 and caspase-8.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-1, caspase-4, caspase-5, caspase-8
Reversible: no
Warning
Toxicity: Standard Handling (A)
Sequence
Z-Trp-Glu(OMe)-His-Asp(OMe)-CH₂F*
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
Analysis Note
single spot by TLC
Other Notes
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Rano, T., et al. 1997. Chem. Biol. 4, 149.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51321602
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 218753-1MG