Catalase from Bovine Liver, 10mL

Catalase from bovine liver is a homotetrameric enzyme that is primarily located in peroxisomes. Activates the decomposition of hydrogen peroxide Natural antioxidant used to study roles of reactive oxygen species Catalyzes the decomposition of hydrogen peroxide into water and oxygen Catalase is a tetramer consisting of 4 equal subunits with a molecular weight of 60 kDa each. Each subunit contains iron bound to a protoheme IX group. The enzyme also strongly binds NADP, which is in close proximity to the heme group (13.7 Å apart). Catalase catalyzes the following reaction: 2 H₂O₂→O₂ + 2 H₂O Catalase can also react with alkylhydrogen peroxides instead of H2O2, such as methylperoxide and ethylperoxide. Catalase does not require any activator for exhibiting its catalytic activity. Catalase activity is constant over the pH range of 4.0-8.5. Catalase is often used as an antioxidant in cell culture media. It has been used to study the role of ROSs in gene expression and apoptosis, mainly in cancer researches. Catalase is used to eliminate H₂O₂ from enzymatic oxidation reactions.