DescriptionCathepsin K (CTSK; EC 3.4.22.38) is a lysosomal cysteine proteinase expressed predominantly in the osteoclasts. It exhibits potent collagenase activity and is involved in bone remodeling and resorption. Mutations in CTSK gene result in pycnodysostosis characterized by osteosclerosis and short stature.Suitability: Suitable for the screening of inhibitors of Cathepsin K.Principle: The Cathepsin K Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSK. CTSK activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λex= 400/ λem= 505 nm), proportional to the enzymatic activity present.}Preparation instructionsPrincipleThe Cathepsin K Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSK. CTSK activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λ/. Specifications and Purity: Sufficient for 100 Fluorometric tests. Related Document: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/C486428-SCI_f1b6b8ccb26052420688595400496baa.pdf.
- UPC:
- 12161503
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 3.53 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C486428-1kit
- Product Size:
- 1kit
- Hazard Statement Codes:
- H412
- Precautionary Statement Codes:
- P273:P501
