Frozen in 20 mM Malonate, pH 5.5, 1 mM EDTA, 400 mM NaCl.The most powerful of the lysosomal proteases. It has a higher specific activity than cathepsin B and H in the degradation of a variety of physiological protein substrates. The level of cathepsin L is a strong predictor of relapse and survival following treatment of a primary breast tumor.Activity: > 1 unit/mg of protein. One unit is defined as the amount of enzyme that hydrolyzes one micromole of Z-Phe-Arg-AFC per minute at 25oC using 400 mM Na Acetate, pH 5.5 with 4 mM EDTA and 8 mM DTT as the activation buffer in the presence of Brij.Product Citations:Armstrong, Andrea, Niklas Mattsson, Hanna Appelqvist, Camilla Janefjord, Linnea Sandin, Lotta Agholme, Bob Olsson et al. "Lysosomal Network Proteins as Potential Novel CSF Biomarkers for Alzheimer’s Disease." Neuromolecular medicine (2013): 1-11Miller, Bailey, Aaron J. Friedman, Hyukjae Choi, James Hogan, J. Andrew McCammon, Vivian Hook, and William H. Gerwick. "The Marine Cyanobacterial Metabolite Gallinamide A Is a Potent and Selective Inhibitor of Human Cathepsin L." Journal of natural products (2013).References:Mason, R.W., Green, G.D.J. and Barrett, A.J. 1985. Biochem. J. 226, 233.Klijn et al. 1998. J. Clin. Onc.16, 1013.Barrett, A.J. and Kirschke, H. 1981. Methods Enzoymol. 80, 535.Tchope, J.R. et al. 1991. Biochem. Biophys. Acta. 1076. 149.
Specification: Extinction Coefficient: 1.28
Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/NP001107-SCI_fabc20f67a1baf355f307f23dd76e0ae.pdf
- UPC:
- 12352204
- Condition:
- New
- Availability:
- 4-8 weeks
- Weight:
- 0.07 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- np001107-25μg
- Product Size:
- 25μg
