CATHEPSIN L INHIBITOR CAA02 1PC X 1MG

Sigma Aldrich

Catalog No.: C15-1301-112
Manufacturer No.: 219502-1MG
Manufacturer Name: Sigma-Aldrich
Quantity: 1
Unit of Measure: MG

Price: $407.76

List Price: $453.06

An epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC 50 = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro .

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Description
Specifications

General description

An epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC₅₀ = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro. During autophagy, it has been shown through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Takahashi, K., et al. 2009. Biol. Pharm. Bull.32, 475.
Ueno, T., et al. 2009. Autophagy5, 878.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:: 41116113
Condition:: New
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: 219502-1MG

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