Biochem/physiol Actions CAY10444 is a selective sphingosine-1-phosphate (S1P) receptor 3 (S1P3: EDG3) antagonist that inhibits 1 µ:M S1P-induced calcium mobilization in HeLa transfectants that express S1P3 over those expressing S1P1/CD363/EDG1
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CAY10444 is a selective sphingosine-1-phosphate (S1P) receptor 3 (S1P3; EDG3) antagonist that inhibits 1 µM S1P-induced calcium mobilization in HeLa transfectants that express S1P3 over those expressing S1P1/CD363/EDG1 (37.6% vs 6.92% inhibition by 10 µM CAY10444).
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