CC-90001 (C09-1120-901)

CC-90001 is a potent, selective and orally active inhibitor of c-Jun N-terminal kinase (JNK) . CC-90001 shows 12.9-fold selectivity for JNK1 over JNK2 in a cell-based model. CC-90001 can be used for the research of idiopathic pulmonary fibrosisIn VitroCC-90001 blocks LPS-induced c-jun phosphorylation with an EC 50 of 480 nM in cellular assays. CC-90001 is 12.9-fold more potent for JNK1 inhibition than JNK2 using JNK1 and JNK2 knockout fibroblasts. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoCC-90001 (3 mg/kg b.i.d.) reduces the development of fibrosis, as evidenced by a 48% reduction in collagen and a 53% reduction in α-smooth muscle actin (α-SMA) in a steatohepatitis model . CC-90001 decreases multiple measures of lung collagen and reduces disease induced increases in α-SMA to nearly baseline levels in a house dust mite model of lung fibrosis . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:JNK1 JNK2. Specifications and Purity: 99%. Molecular Formula: C16H27N5O2. Molecular Weight: 321.42. PubChem CID: 71237511. Isomeric SMILES: C[C@@H]1CC[C@H](C[C@H]1O)NC2=NC(=NC=C2C(=O)N)NC(C)(C)C.