CCG258208 hydrochloride (C09-1121-422)

CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 ( G protein-coupled receptor kinase 2 ) inhibitor ( IC 50 =30 nM) while maintaining 230-fold selectivity over GRK5 ( IC 50 =7.09 μM) and more than 2500-fold selectivity over GRK1 ( IC 50 =Appearance:SolidIC50& Target:GRK2 30 nM (IC 50 ) GRK5 7.1 μM (IC 50 )In Vitro:CCG258208 (Compound 14as) (0-1 μM; 10 min) shows significant improvement in βAR-stimulated contractility in mouse cardiomyocytes. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayIn Vivo:CCG258208 (Compound 14as) (intraperitoneal injection; 10mg/kg; once) treatment shows superior half-life in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: CD-1 mice Dosage: 10 mBiological Activity:CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 ( G protein-coupled receptor kinase 2 ) inhibitor ( IC 50 =30 nM) while maintaining 230-fold selectivity over GRK5 ( IC 50 =7.09 μM) and more than 2500-fold selectivity over GRK1 ( IC 50 =. Specification: 0.98 Molecular Formula: C24H26ClFN4O4 Molecular Weight: 488.94