CCT007093 (C09-0818-568)

CCT007093 is an effective PPM1D inhibitor that selectively reduces viability of human tumour cell lines. PPM1D is a phosphatase where the gene which is aberrantly amplified in a range of common cancers. PPM1D activation results in negative regulation of P53 function by selective inactivation of P38 kinase. Therefore, this enzyme can be considered as a potential therapeutic target for cancer. The present study identified a compound, CCT007093 that selectively reduces viability of human tumour cell lines overexpressing PPM1D through inhibition of this phosphatase. The unique advantage of CCT007093 is its ability to mimic the effects of gene-specific PPM1D RNAi, both in its selectivity for human tumour cells that overexpress PPM1D and also by its reliance on an integral P38 pathway. Specifications and Purity: 98%. Molecular Formula: C15H12OS2. Molecular Weight: 272.39. PubChem CID: 2314623. Isomeric SMILES: C1/C(=C/C2=CC=CS2)/C(=O)/C(=C/C3=CC=CS3)/C1. Related Document: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/C339424-SCI_e2a88375cd05427e94257e40ab50cf28.pdf.