Rat anti Mouse CD155/PVR Antibody, Monoclonal (4.24), could be used for WB, Functional Assays, Flow and so on.ApplicationWB: Use at an assay dependent concentration.Functional Assays: Use at an assay dependent concentration.Flow: Use at an assay dependent concentration.Protein FunctionMediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
Specification: ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, ≥95%(SDS-PAGE&HPLC), Lot by Lot
Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/AB122568-SCI_89e454d94493528d1c351df64dd88385.pdf
- UPC:
- 41116127
- Condition:
- New
- Availability:
- 5-10 days
- Weight:
- 0.07 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Ab122568-100μg
- Product Size:
- 100μg
