CD25/IL-2Ra Fc Chimera, Human, 10ug

The IL-2 receptor system consists of three non-covalently linked subunits termed IL-2Ra, IL- 2Rß, and IL-2R?. The IL-2Ra is a type I transmembrane protein consisting of a 219 amino acid (a.a.) extracellular domain, a 19 a.a. transmembrane domain and a 13 a.a. intracellular domain, which is not involved in the transduction of IL-2 signal. Activated T cells, regulatory T cells (Tregs) and NK cells express high levels of CD25 and expression of the high-affinity IL-2Ra is mostly limited to these cell populations. Signaling via IL-2Ra mediates multiple biological processes in various cell populations, e.g. proliferation and differentiation of B cells and NK cells. A soluble form of IL-2Ra (IL-2Ra) appears in serum, concomitant with its increased expression on cells. The function of the soluble IL-2Ra is unclear. Increased levels of IL-2Ra in biological fluids reportedly correlate with increased T and B cell activation and immune system activation. Increased serum concentration of IL-2Ra has been observed in patients with a variety of inflammatory conditions and in the course of some leukemias and lymphomas. Recombinant Human CD25/IL-2Ra Fc Chimera produced in HEK293 cells is a polypeptide chain containing 427 amino acids with the C-termimal human IgG1 Fc fragment. A fully biologically active molecule, rhCD25/IL-2Ra has a molecular mass of 65~75 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.