Biochem/physiol Actions
CDDO-Im is a bifunctional CDDO analog that enhances NRF2-mediated antioxidant and anti-inflammatory activity by forming not only KEAP1 covalent adducts (Michael adducts via cysteines, acyl adducts via lysines and tyrosines) in the same manner as CDDO and CDDO-Me, but also by covalently transacylating arginine and serine residues in GSTP and cross-linking them to adjacent cysteine residues. CDDO-Im is typically used in the range of 1-40 nM in cultures, 2-5.5 mg/kg via i.p. and 2.5 mg/kg via i.v. in vivo (mice and rats).
- UPC:
- 51383501
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- SML3452-5MG
- CAS:
- 443104-02-7
