Cdk/Crk Inhibitor is a cell-permeable pyrazolo-pyrimidinone compound that acts as a potent, selective, and ATP-competitive inhibitor of Cdks (IC|50|= 48 nM, 15 nM, 9 nM, 10 nM, 71 nM, and 9 nM for Cdc2 (Cdk1)/cyclin B, Cdk2/cyclin E, Cdk3/cyclin E, Cdk5/p35, Cdk7/cyclin H/MAT1, and Cdk9, respectively). It inhibits Cdk4/cyclin D1, Cdk6/cyclin D3, and GSK-3β only at much higher concentrations (IC|50|= 839 nM, 282 nM, and 754 nM, respectively) and exhibits little activity towards a panel of 60 other kinases. Cdk/Crk Inhibitor is a broad-spectrum growth inhibitor toward tumor cells, but not non-transformed quiescent fibroblasts. Specification: >95% Molecular Formula: C23H22Cl2N4O3 Molecular Weight: 473.4 PubChem CID: 135473382 Isomeric SMILES: CC(C)C1=NN(C2=C1C(=O)NC(=N2)CC3=CC=C(C=C3)OCCO)C4=C(C=CC=C4Cl)Cl Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/C336669-SCI_402161d717a7b83c86024a7355839d95.pdf
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C336669-1mg
- CAS:
- 784211-09-2
- Product Size:
- 1mg
- Precautionary Statement Codes:
- P264
