CDK12-IN-3 is a potent and selective CDK12 inhibitor with an IC 50 of 491 nM in enzymatic assay.In VitroCDK12-IN-3 is a highly selective CDK12 inhibitor. CDK12-IN-3 (0.1 μM) shows potent inhibition of phosphorylation of Ser2 on the CTD repeat domain of RNA Pol II as well as growth inhibition of OV90 cells and acute cytotoxicity to THP1 cells.. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:CDK12 491 nM (IC 50 ). Specification: 0.99 Molecular Formula: C23H28F2N8O Molecular Weight: 470.52 PubChem CID: 134691746 Isomeric SMILES: CC(C)N1C=NC2=C(N=C(N=C21)N3CCCC[C@H]3CCO)NCC4=NC5=C(N4)C=CC(=C5F)F
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C647924-100mg
- CAS:
- 2220184-50-7
- Product Size:
- 100mg
