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cdk4 inhibitor

Cdk4 inhibitor

Aladdin

Catalog No.
C09-0818-222
Manufacturer No.
C336666-1mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA
Price: $187.35
List Price: $208.17

Cdk4 Inhibitor is a cell-permeable, unsymmetrical indolocarbazole compound that displays antiproliferative properties. Acts as a potent, selective, and ATP-competitive inhibitor of Cdk4/cyclin D1 (IC|50|= 76 nM). It inhibits the activity of other

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Cdk4 Inhibitor is a cell-permeable, unsymmetrical indolocarbazole compound that displays antiproliferative properties. Acts as a potent, selective, and ATP-competitive inhibitor of Cdk4/cyclin D1 (IC|50|= 76 nM). It inhibits the activity of other Cdk's only at much higher concentrations (IC|50|= 520 nM and 2.1 μM for Cdk2/cyclin E and Cdc2 (Cdk1)/cyclin B, respectively) and shows little activity towards CaMKII, PKA, or GSK-3b (IC|50|≥ 12.4 μM). Shown to inhibit tumor cells growth (IC|50|< 3.0 μM in HCT-116 and NCI-H460 cells) by blocking Rb phosphorylation and inducing G1 cell cycle arrest. Molecular Formula: C20H10BrN3O2 Molecular Weight: 404.22 PubChem CID: 5330797 Isomeric SMILES: C1=CC=C2C(=C1)C3=C4C(=C5C6=C(C=C(C=C6)Br)NC5=C3N2)C(=O)NC4=O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/C336666-SCI_301c0dc8b31d1d0b497aff7d6c491e0f.pdf
UPC:
12352005
Condition:
New
Availability:
8-12 weeks
Weight:
0.96 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
C336666-1mg
CAS:
546102-60-7
Product Size:
1mg
Precautionary Statement Codes:
P264


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