CEAPIN-A7 (C005B-310846)

Catalog No.: C005B-310846
Mfr. No.: SML2330-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $239.37

List Price: $265.97

Biochem/physiol Actions The pyrazole amide Ceapin-A7 is a potent and highly specific ER stress-induced ATF6α: signaling blocker (IC 50 = 590 nM by HEK293T-based ERSE-luciferase reporter assay, ATF6α: target transcripts GRP78/ERO1B/HERPUD1

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Description
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Biochem/physiol Actions

The pyrazole amide Ceapin-A7 is a potent and highly specific ER stress-induced ATF6α signaling blocker (IC₅₀ = 590 nM by HEK293T-based ERSE-luciferase reporter assay, ATF6α target transcripts GRP78/ERO1B/HERPUD1 induction IC₅₀ = 459/522/614 nM in U2OS cells; ER stress by 100 nM Thapsigargin) that does not affect IRE1 or PERK branches of the unfolded protein response (UPR), nor proteolytic processing of its close homolog ATF6β or SREBP. Ceapin-A7 sensitizes U2-OS cells to ER stress-induced death (thapsigargin EC₅₀ = 4.5/7.1 nM with/without 6 μM Ceapin-A7) without impacting the viability of unstressed cells.

UPC:: 51263140
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML2330-5MG
CAS:: 2323027-38-7

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