CEDIRANIB (C005B-310005)

Catalog No.: C005B-310005
Mfr. No.: SML2850-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 25
UOM: MG

Price: $589.40

List Price: $654.89

Biochem/physiol Actions Cediranib (AZD2171) is an orally active anticancer agent and a highly potent ATP-competitive receptor tyrosine kinase (RTK) inhibitor against VEGFR (IC 50 = 5 nM/Flt-1 (VEGFR1), <:1 nM/KDR (VEGFR2), ≤:3 nM/Flt-4

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Description
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Biochem/physiol Actions

Cediranib (AZD2171) is an orally active anticancer agent and a highly potent ATP-competitive receptor tyrosine kinase (RTK) inhibitor against VEGFR (IC₅₀ = 5 nM/Flt-1 (VEGFR1), <1 nM/KDR (VEGFR2), ≤3 nM/Flt-4 (VEGFR3), c-Kit (IC₅₀ = 2 nM), PDGFR1/2 (IC₅₀ = 5/36 nM), and FGFR1 (IC₅₀ = 26 nM). Cediranib exhibits reduced activity against CSF-1R, Src, Abl (IC₅₀ = 110, 130, 260 nM, respectively) and little or no potency toward Flt-3, EGFR, ErbB2 (Her-2/neu), CDK2/4, Aurora A/B, and MEK.

UPC:: 51111735
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML2850-25MG
CAS:: 288383-20-0

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