Celastrol, Celastrus scandens, a compound originally purified from Tripterygium wilfordii, has been shown to be an anti-peroxidative and anti-angiogenic agent. Mechanistic studies suggest that Celastrol suppresses levels of VEGF and Flk-1 receptors, VEGFR-1 and VEGFR-2, which may reduce signal transduction between the two growth factors. Additionally, Celastrol has demonstrated the ability to disrupt critical interaction of Glu33 (Hsp90) and Arg167 (Cdc37) in the superchaperone complex which causes anti-proliferative activity in vitro and inhibit Topo II (topoisomerase II) activity in vitro (IC50 = 7.41 μM). Celastrol, Celastrus scandens is an inhibitor of Hsp90. Specification: analytical standard，≥98% MDL Number: MFCD03424073 Molecular Formula: C29H38O4 Molecular Weight: 450.61 EC Number: 636-472-5 PubChem CID: 122724 Isomeric SMILES: CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/C107671-SCI_bb5fb2ad7a483125cb7698726fa4b60b.pdf
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- Yes
- WeightUOM:
- LB
- MPN:
- C107671-10mg
- CAS:
- 34157-83-0
- Health Hazards:
- Toxic
- Product Size:
- 10mg
- Hazard Statement Codes:
- H301
- Precautionary Statement Codes:
- P264:P270:P330:P405:P501
