Application
Celastrol has been:
- used intraperitoneally to inject into experimental mice to study its role in nonalcoholic fatty liver disease (NAFLD)
- used in culture medium to study its effect on lipopolysaccharide-induced inflammatory injury in human keratinocyte cell culture
- used to study its effect in vitro and in vivo in VCaP cells
Biochem/physiol Actions
Celastrol is a potent antioxidant, and anti-inflammatory agent. It is a novel HSP90 inhibitor (disrupts Hsp90/Cdc37 complex), that exhibits anticancer (anti-angiogenic - suppresses VEGFR expression); antioxidant (inhibits lipid peroxidation) and anti-inflammatory activity (suppresses iNOS and inflammatory cytokine production).
Celastrol is a quinone methide triterpene naturally present in Tripterygium wilfordii. It is useful in treating rheumatoid arthritis. Celastrol prevents the action of proteasome and nuclear factor Κb.
- UPC:
- 51111840
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C0869-50MG
