Interleukins

Biochem/physiol Actions Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury

Biochem/physiol Actions Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury

Interleukin-6 is a pleotropic cytokine involved in hematopoiesis, inflammation and immune response. IL-6 is secreted by macrophages, dendritic cells and B cells, in response to TNF-&#945, PGDF and IL-1.

Recombinant, human soluble interleukin-6 receptor expressed in S. frugiperda insect cells.

Research area: Immunology and Cytokines Human sequence IL-6 is active in murine cells.1 &#181g is equivalent to 7.

Recombinant, mouse interleukin-6 expressed in E. coli .

Biochem/physiol Actions Interleukin-7 is a lymphoid cell growth factor which affects pre-B, pro-B and early T cells. It supports the growth of early B cells and is mitogenic for thymocytes and co-mitogenic with PHA and Con A.

The interleukin-7 human (IL-7) gene is mapped to human chromosome 8q21.13.

Application Interleukin-8 (IL-8) human has ben used to: measure neutrophil chemotoxis study the uptake of apoptotic cells by meningothelial cells study the effect of IL-8 on expression and secretion of urocortin-1 by human umbilical vein

Native pro-MMP-8 from stimulated human neutrophils. MMP-8 is an N-linked, complex glycoprotein that preferentially hydrolyzes Type I collagen versus Types II and III.

Native MMP-9-Lipocalin-TIMP-1 complex from stimulated human neutrophils. The ternary MMP-9/lipocalin/TIMP-1 complex behaves like the Pro-MMP-9/TIMP-1 complex, acting as an inhibitor of active MMPs.

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1&#945 and IL-1&#946 that are produced by the activation of NF-&#954 B transcription