CGP-37157 (C15-1278-674)

Catalog No.: C15-1278-674
Manufacturer No.: C8874-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Price: $292.04

List Price: $324.49

CGP-37157 is a benzothiazepine compound, which is derived from clonazepam. It functions as a sarco/endoplasmic reticulum Ca 2+ ATPase (SERCA) antagonist and ryanodine receptor channels (RyR) agonist.

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Description
Specifications

General description

CGP-37157 is a benzothiazepine compound, which is derived from clonazepam. It functions as a sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA) antagonist and ryanodine receptor channels (RyR) agonist. CGP-37157 regulates intracellular signaling of calcium in smooth, cardiac and skeletal muscle cells and non-muscle systems.

Application

CGP-37157 has been used as a mitochondrial sodium-calcium exchanger (mNCX) inhibitor to study the role of normal mitochondrial calcium dynamics in sustaining dendritic spinogenesis.

Biochem/physiol Actions

Specific inhibitor of mitochondrial Na⁺/Ca²⁺ exchange as well as sarcoplasmic reticulum calcium-stimulated ATPase and possibly other calcium channels.

UPC:: 41115700
Condition:: New
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: C8874-5MG

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