General description
A cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC50 = 360 nM). Enhances the export of Ca2+ from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca2+ channels.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Mitochondrial Na+/Ca2+ exchanger
Product does not compete with ATP.
Reversible: no
Target IC50: 360 nM against mitochondrial Na+/Ca2+ exchanger
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Preparation Note
Dilute in Ca2+-free buffer just prior to use.
Reconstitution
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Jornot, L., et al. 1999. J. Cell Sci.112, 1013.
Babcock, D.F., et al. 1997. J. Cell Biol.136, 833.
Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol.340, 295.
Griffiths, E.J., et al. 1997. Cell Calcium21, 321.
White, R.J., and Reynolds, I.J. 1996, J. Neurosci.16, 5688.
Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol.21, 595.
Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem.268, 938.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 43232605
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 220005-5MG