InformationCH5138303 CH5138303 is an orally available Hsp90 inhibitor with K d of 0.48 nM.TargetsHSP90α (Cell-free assay) 0.48 nM(Kd)In vitroCH5138303 shows high affinity to Hsp90αand potent cell growth inhibitory activity against an HCT116 colorectal cancer cell line and an NCI-N87 gastric cancer cell line with IC50 of 98 nM and 66 nM, respectively. [1] Besides, CH5138303 also demonstrates liver microsomal stability.In vivoCH5138303 (50 mg/kg p.o.) displays high oral bioavailability in mice and produces potent antitumor efficacy in a human NCI-N87 gastric cancer xenograft model.Cell Research(from reference)Cell lines：HCT116 and NCI-N87 cell lines Concentrations：~10 μM Incubation Time：4 days. Specifications and Purity: 10mM in DMSO. Molecular Formula: C19 H18Cl N5 O2 S. Molecular Weight: 415.9. PubChem CID: 25066238. Isomeric SMILES: C1C2=C3C(=CC(=C(C3=CC=C2)C4=NC(=NC(=N4)SCCCC(=O)N)N)Cl)CO1.
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.85 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C427155-1ml
- CAS:
- 959763-06-5
- Product Size:
- 1ml
