InformationCH7233163 is a non-covalent ATP competitive inhibitor ofEGFR-tyrosine kinasewith antitumor activities against tumor with EGFR-Del19/T790M/C797S.TargetsEGFRIn vitroCH7233163 shows potent antitumor activities against tumor with EGFR-Del19/T790M/C797S in vitro. CH7233163 potently inhibits the proliferation of Del19/T790M/C797S_NIH3T3 cells with IC50 of 20 nmol/L. CH7233163 potently and dose-dependently blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. CH7233163 can inhibit Del19/T790M/C797S signaling.In vivoPharmacodynamic study is performed using Del19/T790M/C797S_NIH3T3 xenografted tumors in mice. CH7233163 clearly inhibits EGFR phosphorylation after oral administration and potent tumor regression is observed. CH7233163 has potent therapeutic efficacy against tumors with EGFR-Del19/T790M/C797S in vivo.Cell Research(from reference)Cell lines：NIH3T3 cells (ATCC) Concentrations：8 nM, 40 nM, 200 nM, 1000 nM Incubation Time：0.5 h-24 h, 4-7 days. Specification: 0.98 Molecular Formula: C31H34F3N9O3S Molecular Weight: 669.72
- UPC:
- 51111665
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C414469-25mg
- Product Size:
- 25mg
