Chelerythrine chloride Is an isoquinoline alkaloid isolated from the root of Zanthoxylum simulans, Chelidonium majus L., and other Papaveraceae. It has been reported to be a potent and selective inhibitor of PKC (protein kinase C, IC50=0.66 μM), and an independent activator of MAPK pathways. The compound has been observed to induce apoptosis in HL-60 human promyelocytic leukemia cells. The proposed method of action of apoptotic stimulation is through the inhibition of binding BclXL to Bax or Bad at an IC50 = 1.5 μM. When used in combination with cisplatin inhibition of cell proliferation of non-small cell lung cancer cells was increased in an additive/synergistic pattern. Also through inhibition of thromboxane formation and phosphoinositide breakdown chelerythrine chloride was demonstrated to inhibit rabbit platelet aggregation and release. Chelerythrine Chloride is an inhibitor of Cox-2.A potent and selective inhibitor of protein kinase C.
Specification: Moligand™, ≥98%
MDL Number: MFCD00060717
Molecular Formula: C21H18ClNO4
Molecular Weight: 383.82
EC Number: 223-444-9
PubChem CID: 72311
Isomeric SMILES: C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]
Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/D133831-SCI_09646ea781414ad2209758d6a630be86.pdf
- UPC:
- 51171809
- Condition:
- New
- Availability:
- 5-10 days
- Weight:
- 0.07 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- D133831-100mg
- CAS:
- 3895-92-9
- Product Size:
- 100mg
- Hazard Statement Codes:
- H302+H312+H332:H332:H312:H302:H335:H319:H315
- Precautionary Statement Codes:
- P280:P271:P270:P264:P261
