Organic Building Blocks

The 12,13-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst. The toxicity and biosynthesis of (±)12(13)-EpOME have not been well differentiated from (±)9(10)-EpOME, but are assumed to be essentially the

The 12,13-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst. The toxicity and biosynthesis of (±)12(13)-EpOME have not been well differentiated from (±)9(10)-EpOME, but are assumed to be essentially the

The diol resulting from the soluble epoxide hydrolase opening of (±)12,13-EpOME. The mixture of the methyl ester of this diol and the 9,10 isomer are more cytotoxic than the methyl ester epoxides in renal proximal tubular cells. However, in renal

The diol resulting from the soluble epoxide hydrolase opening of (±)12,13-EpOME. The mixture of the methyl ester of this diol and the 9,10 isomer are more cytotoxic than the methyl ester epoxides in renal proximal tubular cells. However, in renal

Biosynthesized in rat and rabbit liver microsomes by CYP450. Dramatic increases in urinary (±)14,15-DiHETrE, a (±)14(15)-EET metabolite, have been documented by GC/MS in pregnancy induced hypertension. A more stable form used for long-term storage

Biosynthesized in rat and rabbit liver microsomes by CYP450. Dramatic increases in urinary (±)14,15-DiHETrE, a (±)14(15)-EET metabolite, have been documented by GC/MS in pregnancy induced hypertension. A more stable form used for long-term storage

Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity.1 (±)14,(15)-DHET is the urinary metabolite of (±)14,(15)-EET that has been documented by GC-MS to be elevated in pregnancy-induced

Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity.1 (±)14,(15)-DHET is the urinary metabolite of (±)14,(15)-EET that has been documented by GC-MS to be elevated in pregnancy-induced

(±)14,15-DiHETE is an ω-3 fatty acid found in high concentrations in marine organisms: it is also produced in large quantities as a metabolite of eicosapentaenoic acid (EPA) when EPA is incubated with rat liver microsomes and a rat colitis

(±)14,15-DiHETE is an ω-3 fatty acid found in high concentrations in marine organisms: it is also produced in large quantities as a metabolite of eicosapentaenoic acid (EPA) when EPA is incubated with rat liver microsomes and a rat colitis

Electrolyte and fluid transport in the kidney are regulated partially by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation.

Electrolyte and fluid transport in the kidney are regulated partially by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation.