CHIR-090 (C005B-309568)

Catalog No.: C005B-309568
Mfr. No.: SML3092-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 25
UOM: MG

Price: $900.00

List Price: $1,000.00

Biochem/physiol Actions CHIR-090 is a potent, tight-binding inhibitor against LpxC, the zinc-dependent UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase essential for gram negative bacteria lipid A biosynthesis (98% inhibition of E.

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Description
Specifications

Biochem/physiol Actions

CHIR-090 is a potent, tight-binding inhibitor against LpxC, the zinc-dependent UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase essential for gram negative bacteria lipid A biosynthesis (98% inhibition of E. coli & A. aeolicus LpxC by 0.5 μg/mL (1.15 μM) CHIR-090 at pH 7.4; A. aeolicus LpxC Ki = 1.0-1.7 nM). CHIR-090 possesses remarkable antibiotic activity comparable to that of ciprofloxacin against P. aeruginosa PAO1 as well as E. coli R477 and R477 [LpxC G17S] strains by antibacterial disk tests (20 μg/2 μL per spot).

UPC:: 51283007
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3092-25MG
CAS:: 728865-23-4

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