Application
Chlorambucil has been used:
- as an alkylating/chemotherapeutic agent to study its anti-inflammatory effects on amyloidogenesis in mice
- as a positive control to determine the cytotoxicity in murine leukemic monocyte macrophages
- as an adenine-specific DNA-alkylating reagent in the construction of multifunctional conjugate (8950A-Chb(Cl/OH) for mutation-specific DNA alkylation in HeLa S3 cells
Biochem/physiol Actions
Chlorambucil is a nitrogen mustard alkylating agent that acts as an anti-cancer drug. Chlorambucil binds to membranes, RNA, DNA, and proteins. It exhibits anti-inflammatory and anti-tumor activity by DNA cross-linking. Chlorambucil shows therapeutic effects against chronic lymphocytic leukemia (CLL) via a p53-dependent mechanism.
- UPC:
- 51112505
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C0253-10G