General description
Chloroquine is a member of quinolone family and is a weak intercalating agent. Chloroquine is used for treating amebiasis, rheumatoid arthritis, discoid and systemic lupus erythematosus.
Application
DNA intercalator. Also used to increase transfection efficiency.
Chloroquine diphosphate salt has been used :
- in in vitro antiplasmodial assays
- in transfection and infection assays
- in autophagy inhibition
- in differentiation of induced pluripotent stem (iPS) cells into cardiomyocytes
- in flow treatment of infected blood
Biochem/physiol Actions
Standard anti-malarial drug. Substrate for MRP in multidrug resistant cell line and inhibits photoaffinity labeling of MRP by quinoline-based photoactive drug IAAQ (N-[4-[1-hydroxy-2-(dibutylamino)ethyl]quinolin-8-yl]-4-azidosalicylamide).
Features and Benefits
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- UPC:
- 51434106
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C6628-50G