General description
Chlorotrimethylsilane is a chloroorganosilane compound mainly used for silylation reactions.
Application
Chlorotrimethylsilane (TMSCl) can be used as:
- A reagent to protect alcohol and amine groups via the formation of trimethylsilyl ethers and trimethylsilyl amines.
- A catalyst for the preparation of 1,3-diphenyl-2-propenone derivatives (chalcones) as antimicrobial agents.
- A trapping agent for the anions generated during acyloin condensation reaction.
- A better alternative catalyst to the toxic mercuric chloride for the activation of samarium (Sm) during the cyclopropanation of both allylic and α-allenic alcohols.
- A catalyst in the transesterification of triglycerides with alcohols to form fatty acid alkyl esters.
- A reagent along with lithium bromide for the conversion of alcohols to the corresponding bromides.
- A reagent in Fischer glycosidation.
- A source of acid catalyst in the reductive benzylation reaction using benzaldehyde and Et3SiH.
- A reagent to synthesize sodium trimethylsilanethiolate (Me3SiSNa) by reacting with sodium sulfide, which is an odorless alternative method of synthesizing Me3SiSNa from foul-smelling bis(trimethylsilyl)sulfide and sodium methoxide.
- UPC:
- 51412502
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 386529-25ML
