Chlorotrimethylsilane (C15-1279-004)

General description

Chlorotrimethylsilane is a chloroorganosilane compound mainly used for silylation reactions.

Application

Chlorotrimethylsilane (TMSCl) can be used as:       

• A reagent to protect alcohol and amine groups via the formation of trimethylsilyl ethers and trimethylsilyl amines.      
• A catalyst for the preparation of 1,3-diphenyl-2-propenone derivatives (chalcones) as antimicrobial agents.        
• A trapping agent for the anions generated during acyloin condensation reaction.       
• A better alternative catalyst to the toxic mercuric chloride for the activation of samarium (Sm) during the cyclopropanation of both allylic and α-allenic alcohols.
•  A catalyst in the transesterification of triglycerides with alcohols to form fatty acid alkyl esters.        
• A reagent along with lithium bromide for the conversion of alcohols to the corresponding bromides.       
• A reagent in Fischer glycosidation.       
• A source of acid catalyst in the reductive benzylation reaction using benzaldehyde and Et₃SiH.
• A reagent to synthesize sodium trimethylsilanethiolate (Me₃SiSNa) by reacting with sodium sulfide, which is an odorless alternative method of synthesizing Me₃SiSNa from foul-smelling bis(trimethylsilyl)sulfide and sodium methoxide.