General description
Chlorotrimethylsilane is a chloro-organosilane compound mainly used for silylation reactions.
Application
- Chlorotrimethylsilane can be a non-toxic alternative to mercuric chloride as activator in samarium-promoted cyclopropanation of both allylic and α-allenic alcohols.
- It can be used in combination with hexamethyldisilazane for the protection of alcohols by forming trimethylsilyl ethers via silylation.
- It is employed in chloromethylation of polysulfones (PSUs).
- It activates lithium hydride to convert it into a hydride source for the reductive silylation of carbonyl compounds.
- Chlorotrimethylsilane/lithium bromide forms an effective reagent for the conversion of alcohols to bromides.
- Chlorotrimethylsilane/sodium iodide in acetonitrile is a better alternative to iodotrimethylsilane for the cleavage of esters, lactones, carbamates, and ethers. It can also be used for the conversion of alcohols to iodides.
- Chlorotrimethylsilane along with silver or ammonium nitrate forms an efficient regioselective nitrating reagent for the ipso-nitration of arylboronic acids to form the corresponding nitroarenes.
- Chlorotrimethylsilane along with sodium nitrite or nitrate can be used for deoximation reactions.
Other Notes
Silylating agent
- UPC:
- 51412502
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 92360-25ML
