Application
Cholesteryl hemisuccinate tris salt has been used:
- to prepare solubilization buffer for glucan synthase assay
- to prepare immunoprecipitation buffer for immobilization of opioid receptors on paramagnetic beads.
- as a membrane stabilizer for liposomes and protein synaptogyrin-1
- as a component of a folate-modified self-microemulsifying drug delivery system.
- with N-dodecyl β-
D- maltoside (DDM) to solubilize erythrocyte ghosts and chemokine receptor CCR1 - for protein solubilization
Biochem/physiol Actions
Cholesteryl hemisuccinate is an ionizable anionic detergent that stabilizes large unilamellar vesicles. These liposome vesicles act as delivery agents for anticancer drugs, oligonucleotides and antibiotics. Cholesteryl succinate also reportedly exhibits antiproliferative activity and may be clinically useful as antitumor agent.
Preparation Note
Cholesteryl hemisuccinate tris salt yields clear, colorless solution in methanol at 10 mg/ml.
- UPC:
- 51431611
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C6013-5G
