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choline chloride (c15-1256-877)

Choline chloride (C15-1256-877)

Catalog No.
C15-1256-877
Manufacturer No.
C7527-100G
Manufacturer Name
Sigma-Aldrich
Quantity
100
Unit of Measure
GR
Price: $116.42
List Price: $129.35

Choline chloride is a quaternary ammonium salt and associates with hydrogen bond donors (HBD). It is essential for the vital physiological functions and is used as a nutritional additive.

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General description

Choline chloride is a quaternary ammonium salt and associates with hydrogen bond donors (HBD). It is essential for the vital physiological functions and is used as a nutritional additive. Choline is a source of methyl groups for methyl-transfer reactions.

Application

Choline chloride has been used:

  • as a component of choline acetyltransferase (ChAT) buffer and for choline uptake in cultured human neuroblastoma (SK-N-SH) cells
  • for choline standard curve generation for quantifying phospholipase D (PLD) activity
  • as a component of slice solution for the dissection of entorhinal-hippocampal brain slices

Biochem/physiol Actions

The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .

Substrates

Choline acetyltransferase substrate

UPC:
51151535
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
C7527-100G


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