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chromanol 293b (c15-1218-450)

CHROMANOL 293B (C15-1218-450)

Sigma Aldrich

Catalog No.
C15-1218-450
Manufacturer No.
C2615-50MG
Manufacturer Name
Sigma-Aldrich
Quantity
50
Unit of Measure
MG
Price: $1,738.25
List Price: $1,931.39

Chromanol 293B enantiomer is a potent inhibitor of potassium channel protein (KvLQT1). In human atrial myocytes, chromanol 293B inhibits repolarization potassium currents.

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General description

Chromanol 293B enantiomer is a potent inhibitor of potassium channel protein (KvLQT1). In human atrial myocytes, chromanol 293B inhibits repolarization potassium currents. Chromanol 293B improves glucose-stimulated insulin secretion (GSIS) in pancreas by modulating potassium voltage-gated channel (KCNQ1).

Application

Chromanol 293B has been used in the inhibition of calcium and cyclic adenosine monophosphate (cAMP)-activated potassium channels in human epithelial cell lines. Chromanol 293B has been used in patch-clamp electrophysiology studies in cardiomyocytes.

Biochem/physiol Actions

Blocker of the slow delayed rectifier K+ current via KCNQ1 channels

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

UPC:
41115701
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
C2615-50MG

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