Ciproxifan hydrochloride (C15-1201-446)

Sigma-Aldrich

Catalog No.: C15-1201-446
Manufacturer No.: C6492-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Price: $356.33

List Price: $395.92

Biochem/physiol Actions Ciproxifan belongs to a novel chemical series of histamine H 3 -receptor antagonists. In vitro , it behaved as a competitive antagonist at the H 3 autoreceptor controlling 3 H histamine release from synaptosomes and

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Description
Specifications

Biochem/physiol Actions

Ciproxifan belongs to a novel chemical series of histamine H₃-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H₃ autoreceptor controlling ³H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H₃ receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H₃ receptor labeled with ¹²⁵I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H₃-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

UPC:: 51472807
Condition:: New
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: C6492-5MG

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