Cirsiliol (C09-1120-904)

Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.In VitroIn concentrations from 0.01 to 300 μM, cirsiliol causes concentration-dependent relaxation of rat isolated ileum. Cirsiliol may inhibit Ca 2+ influx but stimulates Ca 2+ release from intracellular stores. Treatment with rhamnetin or cirsiliol reduces the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoIn xenograft mouse model, tumor volume is significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Cell AssayNSCLC, NCI-H1299, NCI-H460, WI-26 VA4 and MRC-5 cell lines are exposed to a single dose of γ-rays. Cells are then treated with rhamnetin and cirsiliol (5, 10, 15, 20, 25 μM) dissolved in DMSO for 4 h. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:5-Lipoxygenase. Specifications and Purity: ≥99.0%. Molecular Formula: C17H14O7. Molecular Weight: 330.29. PubChem CID: 160237. Isomeric SMILES: COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC(=C(C=C3)O)O)O)OC.