CK-869 (C15-1237-062)

Catalog No.: C15-1237-062
Mfr. No.: C9124-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $283.96

List Price: $315.51

Application CK-869 has been used as an Arp2/3 complex inhibitor: to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly to induce membrane blebbing in HT1080 fibrosarcoma cells to treat KDM3A-null cells

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Description
Specifications

Application

CK-869 has been used as an Arp2/3 complex inhibitor:

to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
to induce membrane blebbing in HT1080 fibrosarcoma cells
to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis

Biochem/physiol Actions

CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.

CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast. The actin-related protein Arp2/3 complex plays a major role in the regulation of the actin cytoskeleton. Apparently the compound binds to the hydrophobic core of Arp3 and alters its conformation.

UPC:: 41116113
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: C9124-5MG
CAS:: 388592-44-7

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