clasto-Lactacystin β-lactone

clasto|-Lactacystin β-lactone, a synthetic derivative of lactahydrin, is a cell permeable, irreversible and specific inhibitor of the 20S proteasome involved in the ubiquitin-proteasome degradation pathway. Kinetic studies indicate that|clasto|-Lactacystin β-lactone interacts with the proteasome at its catalytic site threonines, which opens the β-lactone ring and allows the proteasome's catalytic hydroxyl group to become acylated.|clasto|-Lactacystin β-lactone has been reported to rapidly enter cells in mammalian cell culture media and to additionally inactivate the proteasome in Jurkat cells in a dose-dependent manner. In addition,|clasto|-Lactacystin β-lactone is reported to inhibit cathepsin A, lead to adipogenesis and induce neurite growth in rat PC12 cells. Specification: >95% Molecular Formula: C10H15NO4 Molecular Weight: 213.23 PubChem CID: 188934 Isomeric SMILES: C[C@H]1[C@@H]2C(C(=O)O2)(NC1=O)C(C(C)C)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/C334447-SCI_95aa3f96b7829ad007e221e7db26a111.pdf