CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT , with IC 50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.Appearance:SolidIC50& Target:DNA Methyltransferase 32 nM (IC 50 ) DNMT1 1.5 nM (Kd) DNMT3A 92 nM (IC 50 ) DNMT3B 1000 nM (IC 50 ) G9a 16 nM (IC 50 )In Vitro:The K d of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC 50 s of 92 nM and 1000 nM, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Biological Activity:CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT , with IC 50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells. Specification: 0.98 Molecular Formula: C29H43Cl3N4O3 Molecular Weight: 602.04
- UPC:
- 41113001
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.09 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C659211-5mg
- Product Size:
- 5mg
