CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases -selective inhibitor, with IC 50 values of 114 nM and 673 nM for PDE5 and HDAC1 , respectively. CM-675 has potential to treat Alzheimer’s diseaseIn VitroCM-675 (29a) shows a significant time-dependent effect on class I HDAC inhibition, particularly towards HDAC2. For HDAC1, its inhibitory potency also increased significantly (~1 log unit) with the pre-incubation time: 673 nM (30 min), 180 nM (4 hours) and 69 nM (6 hours). MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:HDAC1 673 nM (IC 50 , 30 min (time-dependent)) PDE5 114 nM nM (IC 50 ). Specification: 0.99 Molecular Formula: C31H32N6O3 Molecular Weight: 536.62 PubChem CID: 136955224 Isomeric SMILES: CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)CC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5N)OCC)C
- UPC:
- 12352208
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C649600-5mg
- CAS:
- 1872466-47-1
- Product Size:
- 5mg
