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coh34 (c09-1120-286)

COH34 (C09-1120-286)

Aladdin

Catalog No.
C09-1120-286
Manufacturer No.
C648836-100mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA
Price: $2,782.71
List Price: $3,091.90

COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC 50 of 0.37 nM. COH34 binds to the catalytic domain of PARG ( K d =0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factorsIn

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COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC 50 of 0.37 nM. COH34 binds to the catalytic domain of PARG ( K d =0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factorsIn VitroCOH34 efficiently kills PARP inhibitor-resistant cancer cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoCOH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 0.37 nM (PARG). Specifications and Purity: 99%. Molecular Formula: C18H15NOS. Molecular Weight: 293.38. PubChem CID: 135443632.
UPC:
12352005
Condition:
New
Availability:
8-12 weeks
Weight:
1.06 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
C648836-100mg
CAS:
906439-72-3
Product Size:
100mg


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