Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl- p -methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .In VitroCompound 48/80 trihydrochloride (C48/80 trihydrochloride) inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with a similar efficiency; IC 50 values are 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoCompound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3 or 6 h) increases serum serotonin, histamine and corticosterone levels at 0.5 h, but their increases were reduced thereafter. ?/nCompound 48/80 trihydrochloride causes oxidative stress in rat adrenal gland through mast cell degranulation. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 7-week-old Wistar male rats (fasted for 24 hours)Dosage: 0.75 mg/kg Administration: Intraperitoneal injection; Killed after 0.5, 3 or 6 h Result: Serum histamine and serotonin concentrations significantly higher than those in untreated control rats at 0.5 h after treatment. The increased serum histamine and serotonin concentrations in rats decreased time-dependently thereafter. Specification: 10mM in DMSO Molecular Formula: C32H48Cl3N3O3 Molecular Weight: 629.1
- UPC:
- 51261603
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C655805-1ml
- CAS:
- 848035-21-2
- Product Size:
- 1ml
