Corticotropin Releasing Factor Antagonist

Sigma-Aldrich

Catalog No.: C15-1295-257
Manufacturer No.: C2917-.1MG
Manufacturer Name: Sigma-Aldrich
Quantity: 0.1
Unit of Measure: MG

Price: $334.29

List Price: $371.43

Amino Acid Sequence Asp-Leu-Thr-Phe-His-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Ala-Glu-Gln-Ala-Leu-Asn-Arg-Leu-Leu-Glu-Ala-NH2 Biochem/physiol Actions The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits

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Description
Specifications

Amino Acid Sequence

Asp-Leu-Thr-Phe-His-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Ala-Glu-Gln-Ala-Leu-Asn-Arg-Leu-Leu-Glu-Ala-NH2

Biochem/physiol Actions

The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF_2α receptors over human CRF_2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.

Other Notes

Lyophilized from 0.1% TFA in H2O

UPC:: 51421700
Condition:: New
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: C2917-.1MG

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