General description
A cell-permeable potent and selective inhibitor of COX-2 from human monocytes (IC50 = 650 nM) and in whole blood (IC50 = 4.3 µM). Displays only very weak activity against COX-1 from human platelets (IC50 >10 µM) and in whole blood (IC50 >100 µM).
A cell-permeable potent, selective inhibitor of cyclooxygenase-2 (COX-2) (IC50 = 650 nM, human monocytes COX-2). Shown to specifically inhibit COX-2 in human whole blood (IC50 = 4.3 µM). Displays only weak inhibitory activity against COX-1 from human platelets (19% inhibition at 10 µM) and in whole blood (25% inhibition at 100 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
COX-2 from human monocytes
Product does not compete with ATP.
Reversible: no
Target IC50: 650 nM against COX-2 from human monocytes; 4.3 µM against COX-2 in whole blood
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Palomer, A., et al. 2002. J. Med. Chem.45, 1402.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 41116113
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 236011-5MG
