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CPI-360 (C09-0823-178)

Aladdin

Catalog No.
C09-0823-178
Manufacturer No.
C413806-100mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA
Price: $2,638.06
List Price: $2,931.18

InformationCPI-360 CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.TargetsEZH1 102.3 nMIn vitroIn KARPAS-422 cells, CPI-360 potently reduces global

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InformationCPI-360 CPI-360 is a potent, selective,and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.TargetsEZH1 102.3 nMIn vitroIn KARPAS-422 cells, CPI-360 potently reduces global H3K27me3 and H3K27me2 levels with EC50 of 56 nM and 65 nM, respectively. CPI-360 also causes time-dependent transcriptional changes, and affects the viability of Y641N mutant EZH2-containing KARPAS-422 cells. In addition, CPI-360 gradually arrests KARPAS-422 cells in the G1 cell cycle stage followed by the induction of apoptosis.In vivoIn mice bearing KARPAS-422 xenografts, CPI-360 (200 mg/kg, s.c.) reduces tumor growth by 44%. Specifications and Purity: 98%. Molecular Formula: C25H31N3O4. Molecular Weight: 437.53. PubChem CID: 73442743. Isomeric SMILES: CC1=CC(=C(C(=O)N1)CNC(=O)C2=C(N(C3=CC=CC=C32)[C@H](C)C4CCOCC4)C)OC.
UPC:
12352005
Condition:
New
Availability:
2 weeks
Weight:
0.96 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
C413806-100mg
CAS:
1802175-06-9
Product Size:
100mg


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