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CRIPGBM (C15-1722-070)

Sigma Aldrich

Catalog No.
C15-1722-070
Manufacturer No.
SML2681-25MG
Manufacturer Name
Sigma-Aldrich
Quantity
25
Unit of Measure
MG
Price: $625.71
List Price: $695.24

Biochem/physiol Actions cRIPGBM is an apoptosis inducer (GBM-1/-5/-39 EC 50 = 63/95/290 nM: human neural progenitor cells (NPCs)/astrocytes/lung fibroblasts EC 50 = 190/710/960 nM) that binds receptor-interacting protein kinase 2 (RIPK2, RIP2)

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Biochem/physiol Actions

cRIPGBM is an apoptosis inducer (GBM-1/-5/-39 EC50 = 63/95/290 nM; human neural progenitor cells (NPCs)/astrocytes/lung fibroblasts EC50 = 190/710/960 nM) that binds receptor-interacting protein kinase 2 (RIPK2, RIP2) and promotes the formation of a proapoptotic RIPK2/caspase-1 complex. Cell type-selective metabolic redox conversion of RIPGBM to cRIPGBM in glioblastoma multiforme (GBM) cancer stem cells (CSCs) form the basis of selective GBM CSCs apoptosis induction by RIPGBM over non-GBM cultures.

UPC:
51322001
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
SML2681-25MG
Product Size:
25/MG
CAS:
2361988-77-2

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