InformationCrizotinib hydrochloride Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Met and nucleophosmin (NPM)- anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell-based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.TargetsROS1 (Cell-free assay); c-Met (Cell-based assay); NPM-ALK (Cell-based assay) <0.025 nM(Ki); 11 nM; 24 nM. Specification: 0.98 Molecular Formula: C21H23Cl3FN5O Molecular Weight: 486.8 PubChem CID: 71576688 Isomeric SMILES: C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N.Cl Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/C413241-SCI_03fa29476c37db4c76151f49d30370ec.pdf
- UPC:
- 51112518
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.97 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- C413241-50mg
- CAS:
- 1415560-69-8
- Product Size:
- 50mg
- Hazard Statement Codes:
- H302:H315:H319:H335
- Precautionary Statement Codes:
- P261:P305+P351+P338
