CSRM617 HYDROCHLORIDE (C15-1722-199)

Catalog No.: C15-1722-199
Mfr. No.: SML2608-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 25
UOM: MG

Price: $759.67

List Price: $844.07

Biochem/physiol Actions CSRM617 is an ONECUT2 (OC2) inhibitor that directly targets OC2 HOX domain (KD = 7.43 μ:M) and disrupts OC2 target genes promoter binding.

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Description
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Biochem/physiol Actions

CSRM617 is an ONECUT2 (OC2) inhibitor that directly targets OC2 HOX domain (KD = 7.43 μM) and disrupts OC2 target genes promoter binding. CSRM617 blocks OC2-dependent prostate cancer growth in cultures (IC50 = 4-50 μM; 48 h) via apoptosis induction (fold of untreated annexin V population = 2.3/10 μM, 3.5/20 μM; 22Rv1) and exhibits in vivo efficacy against metastases as well as the growth of established 22Rv1 tumor in mice in vivo (50 mg/kg/day ip.).

UPC:: 12352200
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML2608-25MG
CAS:: 1353749-74-2

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