General description
A highly potent octapeptide that acts as a selective and brain penetrating bioavailable µ opioid receptor antagonist (IC50 = 3.5 nM). Used in studies of reward systems and additions.
Biochem/physiol Actions
Primary Target
u Opioid receptpr
Warning
Toxicity: Standard Handling (A)
Sequence
D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (2-7 disulfide bond)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Perry, C., et al., 2013. Behav. Neurosci.127, 535.
Burkett, J. et al. 2011. Neuropsychopharm.36, 2200.
Steinmiller, L., et al., 2008. Psychopharmacol. (Berl).195, 497.
Sterious, S., et al., 2003. J. Pharmacol. Exp. Ther.304, 301.
Abbruscato, T., et al. 1997. J. Pharmacol.280, 402.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 42201515
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 5083160001