CTB (C09-1119-712)

CTB is a potent p300 histone acetyltransferase activator CTB can effectively induce apoptosis in MCF-7 cells .In VitroCTB (10, 50, 100, 150, 200, and 250 μM; 10 min) enhances p300 HAT activity of p300 in a dosedependent manner. ?/nCTB (0-200 μM; 24 hours) inhibits the viability of MCF-7 cells with an IC 50 of 85.43 μM. ?/nCTB (85.43 μM; 24, 48 and 72 h) induces time dependence apoptosis of MCF-7 cells. ?/nCTB (50 uM; 24?h) increases p300/CBP activity , and reduces autophagic flux in primary neurons. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MCF-7 cell Concentration: 0-200 μM Incubation Time: 24 hours Result: Inhibit viability with an IC 50 of 85.43 μM. Apoptosis AnalysisCell Line: MCF-7 cell Concentration: 85.43 μM Incubation Time: 24, 48 and 72 h Result: Iinduced time-dependence apoptosis.Form:SolidIC50& Target:CBP/p300. Specifications and Purity: 99%. Molecular Formula: C16H13ClF3NO2. Molecular Weight: 343.73. PubChem CID: 729859. Isomeric SMILES: CCOC1=CC=CC=C1C(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F.